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The classical milling process is the pearl mill (bead mill), being the NanoCrystal™ technology. Milling media, dispersion medium (generally water), stabilizer and drug are filled into the milling chamber.

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The vertical agitated media mill comprises a cylindrical grinding chamber that is filled with grinding beads of a few millimetres in diameter. The ratio of grinding beads to product is adjusted such that the spaces between the grinding beads are just filled with product.

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